Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

Guillermo Barreto, Andrea Schäfer, Joachim Marhold, Dirk Stach, Suresh K. Swaminathan, Vikas Handa, Gabi Döderlein, Nicole Maltry, Wei Wu, Frank Lyko and Christof Niehrs ()
Additional contact information
Guillermo Barreto: German Cancer Research Center
Andrea Schäfer: German Cancer Research Center
Joachim Marhold: German Cancer Research Center
Dirk Stach: German Cancer Research Center
Suresh K. Swaminathan: German Cancer Research Center
Vikas Handa: German Cancer Research Center
Gabi Döderlein: German Cancer Research Center
Nicole Maltry: German Cancer Research Center
Wei Wu: German Cancer Research Center
Frank Lyko: German Cancer Research Center
Christof Niehrs: German Cancer Research Center

Nature, 2007, vol. 445, issue 7128, 671-675

Abstract: DNA methylation reversed It is increasingly appreciated that DNA methylation, a ubiquitous regulatory mechanism, can be reversed by a process termed 'active demethylation', but its underlying mechanism is poorly understood. Advance in the DNA demethylation field is hampered by a lack of knowledge about the key regulators that could serve as a starting point for unravelling this process. Barreto et al. now report the discovery of one such regulator, Gadd45a, or growth arrest and DNA damage inducible protein 45-alpha. Gadd45a, shown previously to be a target of the p53 and BRCA1 tumour suppressor genes, is acting here by promoting DNA repair to erase methylation marks and thus relieve gene silencing.

Date: 2007
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DOI: 10.1038/nature05515

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