Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript

Igor Martianov, Aroul Ramadass, Ana Serra Barros, Natalie Chow and Alexandre Akoulitchev ()
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Igor Martianov: University of Oxford
Aroul Ramadass: University of Oxford
Ana Serra Barros: University of Oxford
Natalie Chow: University of Oxford
Alexandre Akoulitchev: University of Oxford

Nature, 2007, vol. 445, issue 7128, 666-670

Abstract: Another angle on RNA In recent years it has become clear that non-coding RNAs (that is, RNAs that are not translated into proteins) play a vital role in regulating gene expression. A previously unknown manifestation of that control has been found to operate on the human dihydrofolate reductase (DHFR) gene. The interfering RNA forms a complex with the DHFR gene's promoter region, and in so doing it interferes with the binding of transcription factors. The non-coding RNA is produced only in quiescent cells, leading to repression of the DHFR gene in these conditions.

Date: 2007
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DOI: 10.1038/nature05519

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