Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

Ya-Chieh Hsu, Joshua J. Chern, Yi Cai, Mingyao Liu and Kwang-Wook Choi ()
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Ya-Chieh Hsu: Program in Developmental Biology,
Joshua J. Chern: and
Yi Cai: Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA
Mingyao Liu: Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA
Kwang-Wook Choi: Program in Developmental Biology,

Nature, 2007, vol. 445, issue 7129, 785-788

Abstract: Mixed messages Translationally controlled tumour protein (TCTP) has been implicated in tumorigenesis in mammalian cells, but its in vivo role is still unknown. Now a study in Drosophila reveals an important connection between TCTP and the TSC signalling pathway. Tuberous sclerosis or tuberous sclerosis complex (TSC) is a benign tumour syndrome caused by mutations in either TSC1 or TSC2 tumour suppressor genes, and TSC signalling is a conserved pathway for growth control. The genetic and biochemical evidence in Drosophila suggests that TCTP is a direct regulator of Rheb, a Ras superfamily GTPase that is part of the TSC pathway. TCTP is therefore a potential therapeutic target for tuberous sclerosis.

Date: 2007
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DOI: 10.1038/nature05528

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