Charge- and size-based separation of macromolecules using ultrathin silicon membranes

Christopher C. Striemer (), Thomas R. Gaborski, James L. McGrath and Philippe M. Fauchet
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Christopher C. Striemer: University of Rochester, Rochester, New York 14627, USA
Thomas R. Gaborski: University of Rochester, Rochester, New York 14620, USA
James L. McGrath: University of Rochester, Rochester, New York 14620, USA
Philippe M. Fauchet: University of Rochester, Rochester, New York 14627, USA

Nature, 2007, vol. 445, issue 7129, 749-753

Abstract: Trial separation Procedures for purifying, processing, and identifying biological molecules are becoming increasingly miniaturized and automated. These efforts would benefit from an efficient filter material that could be readily incorporated into microfluidic systems. A team based at the University of Rochester in New York has now developed ultrathin silicon membranes with controllable pore size, and used them for the separation of proteins based on size or charge. The membranes are molecularly thin (15 nm) to maximize transport rates and minimize protein losses yet are extremely tough. These membranes are inexpensive to manufacture, and the silicon platform makes them well suited for use in microfluidic devices.

Date: 2007
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DOI: 10.1038/nature05532

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