Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Mats Hellström (), Li-Kun Phng, Jennifer J. Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano, Keejung Yoon, Janet Rossant, M. Luisa Iruela-Arispe, Mattias Kalén, Holger Gerhardt () and Christer Betsholtz
Additional contact information
Mats Hellström: AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Li-Kun Phng: Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
Jennifer J. Hofmann: Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
Elisabet Wallgard: AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Leigh Coultas: Program for Developmental Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Per Lindblom: Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
Jackelyn Alva: Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
Ann-Katrin Nilsson: AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Linda Karlsson: AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Nicholas Gaiano: Neurology, Neuroscience and Oncology, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Keejung Yoon: Neurology, Neuroscience and Oncology, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Janet Rossant: Program for Developmental Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
M. Luisa Iruela-Arispe: Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
Mattias Kalén: AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Holger Gerhardt: Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
Christer Betsholtz: and

Nature, 2007, vol. 445, issue 7129, 776-780

Abstract: One of two papers showing that delta-like 4/Notch signalling limits angiogenic sprouting and branching by regulating tip cell formation.

Date: 2007
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DOI: 10.1038/nature05571

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