TRAPPI tethers COPII vesicles by binding the coat subunit Sec23

Huaqing Cai, Sidney Yu, Shekar Menon, Yiying Cai, Darina Lazarova, Chunmei Fu, Karin Reinisch, Jesse C. Hay and Susan Ferro-Novick ()
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Huaqing Cai: Howard Hughes Medical Institute and the,
Sidney Yu: Howard Hughes Medical Institute and the,
Shekar Menon: Howard Hughes Medical Institute and the,
Yiying Cai: New Haven, Connecticut 06519, USA
Darina Lazarova: Howard Hughes Medical Institute and the,
Chunmei Fu: New Haven, Connecticut 06519, USA
Karin Reinisch: New Haven, Connecticut 06519, USA
Jesse C. Hay: The University of Montana, Missoula, Montana 59812-4824, USA
Susan Ferro-Novick: Howard Hughes Medical Institute and the,

Nature, 2007, vol. 445, issue 7130, 941-944

Abstract: The tethering complex TRAPPI initiates the interaction of a transport vesicle with its target membrane by binding to the cargo adaptor complex of the coat complex COPII. These findings imply that coat proteins and their associated cargo help direct a vesicle to its correct intracellular destination.

Date: 2007
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DOI: 10.1038/nature05527

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