Can osteoclasts be excluded?

T. John Martin () and Gregory R. Mundy
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T. John Martin: St Vincent's Institute of Medical Research, Fitzroy
Gregory R. Mundy: Vanderbilt Centre for Bone Biology, 1235 Medical Research Building IV

Nature, 2007, vol. 445, issue 7130, E19-E19

Abstract: Abstract Arising from: D. H. Jones et al. Nature 440, 692–696 (2006)10.1038/nature04524 ; Jones et al. reply The RANK/RANKL signalling mechanism is the final common pathway of osteoclast formation and activity1. Inhibitors of RANK ligand (RANKL) that bind to RANK (for 'receptor activator of NF-κB'), such as osteoprotegerin (OPG), neutralizing antibodies against RANKL and soluble RANK antagonists, are well described inhibitors of bone metastasis in preclinical and clinical models, presumably because of their effects on osteoclasts2. Jones et al.3 show that OPG inhibits bone metastasis after intracardiac injection of B16F10 murine melanoma cells, but claim that bone metastases are entirely independent of osteoclast formation and bone resorption: rather, they are caused by an effect on cell migration through RANK. However, we question whether these surprising conclusions are rigorously supported by their data3.

Date: 2007
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DOI: 10.1038/nature05657

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