Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

Heather J. Painter, Joanne M. Morrisey, Michael W. Mather and Akhil B. Vaidya ()
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Heather J. Painter: Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
Joanne M. Morrisey: Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
Michael W. Mather: Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
Akhil B. Vaidya: Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA

Nature, 2007, vol. 446, issue 7131, 88-91

Abstract: One trick pony The mitochondrial electron transport chain of the malaria parasite Plasmodium falciparum serves only one function, it seems. Its sole remaining purpose is to make ubiquinone, required as an electron acceptor for a pyrimidine biosynthesis enzyme. Many single-cell eukaryotes have lost their mitochondrial genomes during evolution, and P. falciparum seems to be close to that state. The parasite's electron transport system is of particular interest as a target for antimalarials such as proguanil

Date: 2007
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DOI: 10.1038/nature05572

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