A single type of progenitor cell maintains normal epidermis

Elizabeth Clayton, David P. Doupé, Allon M. Klein, Douglas J. Winton, Benjamin D. Simons and Philip H. Jones ()
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Elizabeth Clayton: MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK
David P. Doupé: MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK
Allon M. Klein: Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK
Douglas J. Winton: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Benjamin D. Simons: Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK
Philip H. Jones: MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK

Nature, 2007, vol. 446, issue 7132, 185-189

Abstract: Skin renewal gets simpler For more than 30 years, the accepted model of epithelial homeostasis has assumed that skin tissue is maintained by two separate populations of progenitor cells. Self-renewing stem cells were thought to give rise to short-lived progenitors that in turn form the new epidermis. Clayton et al. now suggest that this hypothesis can be replaced with a simpler model in which a single type of progenitor cell undergoes asymmetric division at a rate that ensures epidermal homeostasis.

Date: 2007
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DOI: 10.1038/nature05574

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