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Structure of an ABC transporter in complex with its binding protein

Kaspar Hollenstein, Dominik C. Frei and Kaspar P. Locher ()
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Kaspar Hollenstein: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Dominik C. Frei: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Kaspar P. Locher: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland

Nature, 2007, vol. 446, issue 7132, 213-216

Abstract: The structure of a putative molybdate transporter (ModB2C2) is presented in complex with its cognate binding protein ModA. These results help provide the structural basis for the ATP-driven transport mechanism of both clinically relevant multi-drug ABC exporters and of ABC importers facilitating bacterial nutrient uptake.

Date: 2007
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DOI: 10.1038/nature05626

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