A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors

Lolitika Mandal, Julian A. Martinez-Agosto, Cory J. Evans, Volker Hartenstein and Utpal Banerjee ()
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Lolitika Mandal: Cell and Developmental Biology, Molecular Biology Institute
Julian A. Martinez-Agosto: Mattel Children’s Hospital at UCLA, University of California, Los Angeles, Los Angeles, California 90095, USA
Cory J. Evans: Cell and Developmental Biology, Molecular Biology Institute
Volker Hartenstein: Cell and Developmental Biology, Molecular Biology Institute
Utpal Banerjee: Cell and Developmental Biology, Molecular Biology Institute

Nature, 2007, vol. 446, issue 7133, 320-324

Abstract: Signals in the blood This week, two papers from separate groups define a signalling centre in the Drosophila lymph gland that controls maintenance of blood cell precursors. Signals generated in the posterior signalling centre of the lymph gland control the balance of progenitors and differentiating blood cells through JAK/STAT and Notch signalling pathways. Mandal et al. also show that the signalling centre is specified early in embryonic development by the homeotic gene Antennapedia. And Krzemień et al. show that Notch signalling controls Collier, the Drosophila equivalent of mammalian early B cell factor. This work suggests that the Drosophila model for blood development could be an important tool for genetic manipulation.

Date: 2007
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DOI: 10.1038/nature05585

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