Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

L. Pastorino, A. Sun, P.-J. Lu, X. Z. Zhou, M. Balastik, G. Finn, G. Wulf, J. Lim, S.-H. Li, X. Li, W. Xia, L. K. Nicholson and K. P. Lu

Nature, 2007, vol. 446, issue 7133, 342-342

Abstract: Nature 440, 528–534 (2006) During editing to meet Nature’s limits on length, we removed a reference to an earlier paper1 reporting that the prolyl isomerase Pin1 promotes production of Alzheimer’s amyloid-β (Aβ) from β-cleaved amyloid precursor protein (APP). That paper reported that Pin1 did not bind to full-length APP, but rather to the phosphorylated Thr 668–Pro motif of the carboxy-terminal C99 fragment of APP; Aβ production in Pin1-knockout mice was reduced only from this fragment.

Date: 2007
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DOI: 10.1038/nature05606

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