The molecular choreography of a store-operated calcium channel

Richard S. Lewis ()
Additional contact information
Richard S. Lewis: Stanford University School of Medicine, Stanford, California 94305, USA

Nature, 2007, vol. 446, issue 7133, 284-287

Abstract: A good SOCE Store-operated Ca2+ entry (SOCE) is a signalling process whereby a decrease in the concentration of Ca2+ in the endoplasmic reticulum (ER) triggers Ca2+ influx via channels in the plasma membrane. SOCE has been detected in many types of excitable and non-excitable cells, involved in essential functions such as secretion and immunity. Despite intense interest in SOCE, its molecular basis remained elusive until recently, when genes for the ER Ca2+ sensor and Ca2+ release-activated Ca2+ (CRAC) channel were identified. A molecular picture of CRAC channel activation and SOCE is now starting to emerge.

Date: 2007
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature05637 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05637

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05637

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().