Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre

Joanna Krzemień, Laurence Dubois, Rami Makki, Marie Meister, Alain Vincent and Michèle Crozatier ()
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Joanna Krzemień: Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France
Laurence Dubois: Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France
Rami Makki: Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France
Marie Meister: UPR 9022 du CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France
Alain Vincent: Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France
Michèle Crozatier: Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France

Nature, 2007, vol. 446, issue 7133, 325-328

Abstract: Signals in the blood This week, two papers from separate groups define a signalling centre in the Drosophila lymph gland that controls maintenance of blood cell precursors. Signals generated in the posterior signalling centre of the lymph gland control the balance of progenitors and differentiating blood cells through JAK/STAT and Notch signalling pathways. Mandal et al. also show that the signalling centre is specified early in embryonic development by the homeotic gene Antennapedia. And Krzemień et al. show that Notch signalling controls Collier, the Drosophila equivalent of mammalian early B cell factor. This work suggests that the Drosophila model for blood development could be an important tool for genetic manipulation.

Date: 2007
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DOI: 10.1038/nature05650

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