Peptide bond formation destabilizes Shine–Dalgarno interaction on the ribosome

Sotaro Uemura, Magdalena Dorywalska, Tae-Hee Lee, Harold D. Kim, Joseph D. Puglisi () and Steven Chu ()
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Sotaro Uemura: Department of Physics,
Magdalena Dorywalska: Stanford University, Stanford, California 94305, USA
Tae-Hee Lee: Department of Physics,
Harold D. Kim: Department of Physics,
Joseph D. Puglisi: Stanford University, Stanford, California 94305, USA
Steven Chu: Department of Physics,

Nature, 2007, vol. 446, issue 7134, 454-457

Abstract: How the Shine–Dalgarno (SD) sequence affects binding of the ribosome to mRNA is examined by measuring the force required to tear the ribosome from an mRNA with or without the SD sequence. This finds that the SD sequence stabilizes the ribosome–mRNA interaction before the first peptide bond is formed, but that once this occurs, the SD sequence can no longer stabilize it.

Date: 2007
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DOI: 10.1038/nature05625

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