Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism

Douglas A. Hattendorf, Anna Andreeva, Akanksha Gangar, Patrick J. Brennwald () and William I. Weis ()
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Douglas A. Hattendorf: Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305-5126, USA
Anna Andreeva: University of North Carolina, 538 Taylor Hall, Chapel Hill, North Carolina, 27599-7090, USA
Akanksha Gangar: University of North Carolina, 538 Taylor Hall, Chapel Hill, North Carolina, 27599-7090, USA
Patrick J. Brennwald: University of North Carolina, 538 Taylor Hall, Chapel Hill, North Carolina, 27599-7090, USA
William I. Weis: Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305-5126, USA

Nature, 2007, vol. 446, issue 7135, 567-571

Abstract: The crystal structure of Sro7 and its interaction with the SNARE Sec9p is described. The structure reveals two WD40 β-propeller domains followed by a 60-residue tail. A mutant lacking the tail binds to the SNARE domain of Sec9 and inhibits assembly of the exocytic SNARE complex.

Date: 2007
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DOI: 10.1038/nature05635

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