Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

Fumiaki Ohtake, Atsushi Baba, Ichiro Takada, Maiko Okada, Kei Iwasaki, Hiromi Miki, Sayuri Takahashi, Alexander Kouzmenko, Keiko Nohara, Tomoki Chiba, Yoshiaki Fujii-Kuriyama and Shigeaki Kato ()
Additional contact information
Fumiaki Ohtake: ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
Atsushi Baba: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Ichiro Takada: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Maiko Okada: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Kei Iwasaki: ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
Hiromi Miki: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Sayuri Takahashi: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Alexander Kouzmenko: ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
Keiko Nohara: National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan
Tomoki Chiba: Graduate School of Life and Environmental Sciences, and,
Yoshiaki Fujii-Kuriyama: TARA Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Japan
Shigeaki Kato: ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

Nature, 2007, vol. 446, issue 7135, 562-566

Abstract: Dioxin toxicity The dioxins, a family of halogenated organic compounds formed as by-products of various industrial processes, are toxic because of their interaction with signalling pathways linked to steroid hormone function. A possible mechanism for this toxicity has now been found: dioxins form atypical ubiquitin ligases that mark out members of the nuclear steroid receptor family of gene transcription factors for untimely degradation.

Date: 2007
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DOI: 10.1038/nature05683

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