Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada and Shimon Sakaguchi ()
Additional contact information
Masahiro Ono: Institute for Frontier Medical Sciences, and
Hiroko Yaguchi: Tumor Endocrinology Project, and,
Naganari Ohkura: Tumor Endocrinology Project, and,
Issay Kitabayashi: National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan
Yuko Nagamura: Tumor Endocrinology Project, and,
Takashi Nomura: Institute for Frontier Medical Sciences, and
Yoshiki Miyachi: Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Toshihiko Tsukada: Tumor Endocrinology Project, and,
Shimon Sakaguchi: Institute for Frontier Medical Sciences, and

Nature, 2007, vol. 446, issue 7136, 685-689

Abstract: Immunity tamed CD25+CD4+ regulatory T cells or 'Tregs' are vital to the immune system, suppressing aberrant or excessive immune responses such as autoimmune disease and allergy. Ono et al. find that Tregs act via the interaction of the transcription factors AML1/Runx1 and Foxp3. This interaction is therefore a potential therapeutic target for controlling immune responses.

Date: 2007
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DOI: 10.1038/nature05673

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