Myc deletion rescues Apc deficiency in the small intestine

Owen J. Sansom (), Valerie S. Meniel, Vanesa Muncan, Toby J. Phesse, Julie A. Wilkins, Karen R. Reed, J. Keith Vass, Dimitris Athineos, Hans Clevers and Alan R. Clarke
Additional contact information
Owen J. Sansom: The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK
Valerie S. Meniel: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Vanesa Muncan: Hubrecht Laboratory, Nederlands Institute for Developmental Biology, Upsalalaan 8, 3584 CT Utrecht, The Netherlands
Toby J. Phesse: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Julie A. Wilkins: The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK
Karen R. Reed: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
J. Keith Vass: The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK
Dimitris Athineos: The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK
Hans Clevers: Hubrecht Laboratory, Nederlands Institute for Developmental Biology, Upsalalaan 8, 3584 CT Utrecht, The Netherlands
Alan R. Clarke: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK

Nature, 2007, vol. 446, issue 7136, 676-679

Abstract: Deregulation of the Wnt signalling pathway has been implicated in the development of cancer, including colorectal tumours. This paper shows that regulation of the transcription factor c-Myc is the most critical target for Wnt signalling in the early stages of intestinal neoplasias.

Date: 2007
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DOI: 10.1038/nature05674

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