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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

Sean R. Collins, Kyle M. Miller, Nancy L. Maas, Assen Roguev, Jeffrey Fillingham, Clement S. Chu, Maya Schuldiner, Marinella Gebbia, Judith Recht, Michael Shales, Huiming Ding, Hong Xu, Junhong Han, Kristin Ingvarsdottir, Benjamin Cheng, Brenda Andrews, Charles Boone, Shelley L. Berger, Phil Hieter, Zhiguo Zhang, Grant W. Brown, C. James Ingles, Andrew Emili, C. David Allis, David P. Toczyski, Jonathan S. Weissman (), Jack F. Greenblatt () and Nevan J. Krogan
Additional contact information
Sean R. Collins: Department of Cellular and Molecular Pharmacology,
Kyle M. Miller: Cancer Research Institute, University of California, San Francisco, California 94115, USA
Nancy L. Maas: Cancer Research Institute, University of California, San Francisco, California 94115, USA
Assen Roguev: Department of Cellular and Molecular Pharmacology,
Jeffrey Fillingham: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Clement S. Chu: Department of Cellular and Molecular Pharmacology,
Maya Schuldiner: Department of Cellular and Molecular Pharmacology,
Marinella Gebbia: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Judith Recht: Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
Michael Shales: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Huiming Ding: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Hong Xu: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Junhong Han: Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
Kristin Ingvarsdottir: Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Benjamin Cheng: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Brenda Andrews: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Charles Boone: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Shelley L. Berger: Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Phil Hieter: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Zhiguo Zhang: Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
Grant W. Brown: University of Toronto, Toronto, Ontario M5S 1A8, Canada
C. James Ingles: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Andrew Emili: University of Toronto, Toronto, Ontario M5S 3E1, Canada
C. David Allis: Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
David P. Toczyski: Cancer Research Institute, University of California, San Francisco, California 94115, USA
Jonathan S. Weissman: Department of Cellular and Molecular Pharmacology,
Jack F. Greenblatt: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Nevan J. Krogan: Department of Cellular and Molecular Pharmacology,

Nature, 2007, vol. 446, issue 7137, 806-810

Abstract: An epistatic miniarray profile allows identification of multiprotein complexes involved in various aspects of chromosome biology. In one pathway, the histone acetyltransferase Rtt109 is found to modify histone H3 lysine 56 during DNA replication.

Date: 2007
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DOI: 10.1038/nature05649

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