Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

Matthew J. Evans, Thomas von Hahn, Donna M. Tscherne, Andrew J. Syder, Maryline Panis, Benno Wölk, Theodora Hatziioannou, Jane A. McKeating, Paul D. Bieniasz and Charles M. Rice ()
Additional contact information
Matthew J. Evans: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Thomas von Hahn: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Donna M. Tscherne: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Andrew J. Syder: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Maryline Panis: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Benno Wölk: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Theodora Hatziioannou: Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York 10016, USA
Jane A. McKeating: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Paul D. Bieniasz: Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York 10016, USA
Charles M. Rice: Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA

Nature, 2007, vol. 446, issue 7137, 801-805

Abstract: Hepatitis C co-factor Claudin-1, a tight junction protein expressed in human liver, has been identified as an essential entry co-factor for hepatitis C virus. Like the CD81 co-receptor, claudin-1 spans the cell membrane four times with two extracellular loops. It functions in the hepatitis C virus entry process at a post-binding and pre-fusion step. This discovery provides insights into the mechanism of viral entry into liver cells, and a potential new target for antiviral drugs.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature05654 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:446:y:2007:i:7137:d:10.1038_nature05654

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05654

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().