Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers

Ananda K. Sarkar, Marijn Luijten, Shunsuke Miyashima, Michael Lenhard, Takashi Hashimoto, Keiji Nakajima, Ben Scheres, Renze Heidstra and Thomas Laux ()
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Ananda K. Sarkar: Institute of Biology III, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany
Marijn Luijten: Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Shunsuke Miyashima: Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
Michael Lenhard: Institute of Biology III, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany
Takashi Hashimoto: Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
Keiji Nakajima: Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
Ben Scheres: Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Renze Heidstra: Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Thomas Laux: Institute of Biology III, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany

Nature, 2007, vol. 446, issue 7137, 811-814

Abstract: Root and branch stem cells Plants have two apparently distinct stem cell niches, in the root and stem meristems, dividing perpetually to produce new tissues and organs. Previous studies have highlighted the different modes of development and different control genes in the two systems, but Sarkar et al. now show that there is a strong mechanistic link between them. The signalling centres of both niches utilize related transcription factors, WUSCHEL in the shoot and WOX5 in the roots, to maintain neighbouring stem cells undifferentiated, and these two factors act in both meristems to maintain normal function. This finding provides molecular evidence that the stem cell regulatory system originated before root and shoots separated in land plants from which the current higher plants are derived.

Date: 2007
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DOI: 10.1038/nature05703

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