Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

Liana F. Lareau, Maki Inada, Richard E. Green, Jordan C. Wengrod and Steven E. Brenner ()
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Liana F. Lareau: Departments of Molecular and Cell Biology and,
Maki Inada: Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
Richard E. Green: Departments of Molecular and Cell Biology and,
Jordan C. Wengrod: Departments of Molecular and Cell Biology and,
Steven E. Brenner: Departments of Molecular and Cell Biology and,

Nature, 2007, vol. 446, issue 7138, 926-929

Abstract: A function is defined for ultraconserved elements (UCEs), extragenic regions of eukaryotic genomes can show high degrees of conservation across species. It is also found that when alternative splicing (mediated by splicing regulator proteins) leads to UCE incorporation into the splicing regulator protein's mRNA, the mRNA is targeted for degradation. Thus, the UCEs help promote negative feedback regulation of the splicing regulator gene expression.

Date: 2007
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DOI: 10.1038/nature05676

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