Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

S. K. Reddy, M. Rape, W. A. Margansky and M. W. Kirschner ()
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S. K. Reddy: Harvard Medical School, and
M. Rape: Harvard Medical School, and
W. A. Margansky: Harvard Medical School, and
M. W. Kirschner: Harvard Medical School, and

Nature, 2007, vol. 446, issue 7138, 921-925

Abstract: Cell division control During cell division the spindle checkpoint ensures that chromosome segregation is delayed until all chromosomes are properly attached to the mitotic spindle. Two papers now identify a new regulatory mechanism that controls the spindle checkpoint. This involves the fine-tuned ubiquitination and de-ubiquitination of a coactivator of the anaphase promoting complex APC/C to regulate the timing of APC/C activation and thereby the onset of anaphase.

Date: 2007
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DOI: 10.1038/nature05734

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