Unusual sugar biosynthesis and natural product glycodiversification

Christopher J. Thibodeaux, Charles E. Melançon and Hung-wen Liu
Additional contact information
Christopher J. Thibodeaux: Institute for Cellular and Molecular Biology, 1 University Station A4810, University of Texas at Austin
Charles E. Melançon: 1 University Station A5300, University of Texas at Austin
Hung-wen Liu: Institute for Cellular and Molecular Biology, 1 University Station A4810, University of Texas at Austin

Nature, 2007, vol. 446, issue 7139, 1008-1016

Abstract: Abstract The enzymes involved in the biosynthesis of carbohydrates and the attachment of sugar units to biological acceptor molecules catalyse an array of chemical transformations and coupling reactions. In prokaryotes, both common sugar precursors and their enzymatically modified derivatives often become substituents of biologically active natural products through the action of glycosyltransferases. Recently, researchers have begun to harness the power of these biological catalysts to alter the sugar structures and glycosylation patterns of natural products both in vivo and in vitro. Biochemical and structural studies of sugar biosynthetic enzymes and glycosyltransferases, coupled with advances in bioengineering methodology, have ushered in a new era of drug development.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature05814 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05814

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05814

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().