Heparan sulphate proteoglycans fine-tune mammalian physiology

Joseph R. Bishop (), Manuela Schuksz and Jeffrey D. Esko
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Joseph R. Bishop: University of California, San Diego
Manuela Schuksz: University of California, San Diego
Jeffrey D. Esko: University of California, San Diego

Nature, 2007, vol. 446, issue 7139, 1030-1037

Abstract: Abstract Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these interactions is exemplified by phenotypic studies of mice and humans bearing mutations in the core proteins or the biosynthetic enzymes responsible for assembling the heparan sulphate chains.

Date: 2007
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DOI: 10.1038/nature05817

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