Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Christopher N. Scanlan, John Offer, Nicole Zitzmann and Raymond A. Dwek
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Christopher N. Scanlan: Glycobiology Institute, University of Oxford
John Offer: Scripps Oxford Laboratory, University of Oxford
Nicole Zitzmann: Glycobiology Institute, University of Oxford
Raymond A. Dwek: Glycobiology Institute, University of Oxford

Nature, 2007, vol. 446, issue 7139, 1038-1045

Abstract: Abstract The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.

Date: 2007
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DOI: 10.1038/nature05818

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