Template switching during break-induced replication

Catherine E. Smith, Bertrand Llorente and Lorraine S. Symington ()
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Catherine E. Smith: Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA
Bertrand Llorente: Unité de Génétique Moléculaire des Levures (URA2171 CNRS and UFR927 Université Pierre et Marie Curie), Institut Pasteur, 25 rue du docteur Roux, F-75724 Paris, Cedex 15, France
Lorraine S. Symington: Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA

Nature, 2007, vol. 447, issue 7140, 102-105

Abstract: One way of repairing a DNA break is through invasion of an end into a homologous, intact duplex, which can set up a replication fork. However, this work shows that the initial invasion events are unstable in the vicinity of the break, so that multiple rounds of invasion and dissociation can take place.

Date: 2007
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DOI: 10.1038/nature05723

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