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A positive feedback mechanism governs the polarity and motion of motile cilia

Brian Mitchell, Richard Jacobs, Julie Li, Shu Chien and Chris Kintner ()
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Brian Mitchell: The Salk Institute for Biological Studies, La Jolla, California 92186, USA
Richard Jacobs: The Salk Institute for Biological Studies, La Jolla, California 92186, USA
Julie Li: University of California San Diego, La Jolla, California 92093, USA
Shu Chien: University of California San Diego, La Jolla, California 92093, USA
Chris Kintner: The Salk Institute for Biological Studies, La Jolla, California 92186, USA

Nature, 2007, vol. 447, issue 7140, 97-101

Abstract: On cells with motile cilia, cilia not only generate flow along a specific axis, but are involved in sensing and responding to that flow in a way that influences cell polarity. This model suggests a new paradigm for how polarity can be generated in a developing tissue, which will be of general interest to all developmental biologists.

Date: 2007
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DOI: 10.1038/nature05771

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