The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Travis H. Stracker, Monica Morales, Suzana S. Couto, Hussein Hussein and John H. J. Petrini ()
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Travis H. Stracker: Molecular Biology and Genetics, Sloan-Kettering Institute, and
Monica Morales: Molecular Biology and Genetics, Sloan-Kettering Institute, and
Suzana S. Couto: Pathology and Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, and
Hussein Hussein: Molecular Biology and Genetics, Sloan-Kettering Institute, and
John H. J. Petrini: Molecular Biology and Genetics, Sloan-Kettering Institute, and

Nature, 2007, vol. 447, issue 7141, 218-221

Abstract: Although the C-terminal domain of the protein Nbs1 is required for interaction with ATM, it is unexpectedly not required for most downstream ATM-dependent damage repair events. Instead, the most notable effect seen when this interaction domain is absent is loss of the ability of ATM to induce apoptosis.

Date: 2007
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DOI: 10.1038/nature05740

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