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The human RNA kinase hClp1 is active on 3′ transfer RNA exons and short interfering RNAs

Stefan Weitzer and Javier Martinez ()
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Stefan Weitzer: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 3, A-1030 Vienna, Austria
Javier Martinez: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 3, A-1030 Vienna, Austria

Nature, 2007, vol. 447, issue 7141, 222-226

Abstract: During tRNA splicing, the 5' end of the 3' exon must be phosphorylated for subsequent ligation of the two exons to occur. The kinase which performs this reaction, human Clp1, is identified, is also able to phosphorylate exogenously introduced siRNAs.

Date: 2007
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DOI: 10.1038/nature05777

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