RNA-templated DNA repair

Francesca Storici, Katarzyna Bebenek, Thomas A. Kunkel, Dmitry A. Gordenin and Michael A. Resnick ()
Additional contact information
Francesca Storici: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA
Katarzyna Bebenek: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA
Thomas A. Kunkel: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA
Dmitry A. Gordenin: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA
Michael A. Resnick: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA

Nature, 2007, vol. 447, issue 7142, 338-341

Abstract: Although RNA is used to synthesize DNA by specialized enzymes such as reverse transcriptase and telomerase, it has never been shown to be used directly in DNA repair. Here Resnick and colleagues find that short RNA oligonucleotides which are complementary to the sequences at a DNA double-strand break can serve as a template for repair by the normal replicative DNA polymerases, suggesting that information contained in an RNA molecule could be transferred into the genome.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature05720 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:447:y:2007:i:7142:d:10.1038_nature05720

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05720

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().