SUMOylation regulates kainate-receptor-mediated synaptic transmission

Stéphane Martin, Atsushi Nishimune, Jack R. Mellor and Jeremy M. Henley ()
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Stéphane Martin: MRC Centre for Synaptic Plasticity, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Atsushi Nishimune: MRC Centre for Synaptic Plasticity, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Jack R. Mellor: MRC Centre for Synaptic Plasticity, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Jeremy M. Henley: MRC Centre for Synaptic Plasticity, University Walk, University of Bristol, Bristol, BS8 1TD, UK

Nature, 2007, vol. 447, issue 7142, 321-325

Abstract: Wrestling with proteins SUMO, the Small Ubiquitin-like MOdifier, is known to conjugate with target protein substrates in the nucleus, where among other things, it controls gene transcription. Now SUMO has been found also to control the turnover of a neurotransmitter receptor — the kainate receptor. This suggests that SUMO may influence brain function by hooking up to other proteins at the junctions between nerve cells.

Date: 2007
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DOI: 10.1038/nature05736

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