Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Masamitsu Sato () and Takashi Toda ()
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Masamitsu Sato: Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln’s Inn Fields Laboratories, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
Takashi Toda: Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln’s Inn Fields Laboratories, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK

Nature, 2007, vol. 447, issue 7142, 334-337

Abstract: In higher eukaryotes, during mitosis the nuclear transport system Ran organises spindle formation, but in yeast, such targets for Ran had not yet been identified. Here Sato and Toda show that in fission yeast, the microtubule-associated protein Alp7/TACC is a critical target for Ran and contributes to spindle formation.

Date: 2007
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DOI: 10.1038/nature05773

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