Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

Chang Liu, Siming Li, Tiecheng Liu, Jimo Borjigin and Jiandie D. Lin ()
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Chang Liu: Life Sciences Institute and Department of Cell & Developmental Biology
Siming Li: Life Sciences Institute and Department of Cell & Developmental Biology
Tiecheng Liu: University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Jimo Borjigin: University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Jiandie D. Lin: Life Sciences Institute and Department of Cell & Developmental Biology

Nature, 2007, vol. 447, issue 7143, 477-481

Abstract: Clocking on Many physiological parameters, such as body temperature, blood glucose and heart rate, undergo cyclic changes with the 24-hour rhythms of the circadian clock. It has been a mystery how the metabolic pathways are coupled to the clockwork, but now experiments in mice suggest that the metabolic transcriptional regulator PGC-1α is a key factor. Mice lacking PGC-1α display abnormal diurnal rhythms of activity, body temperature and metabolic rate. At the mechanistic level, PGC-1α regulates clock gene expression through coactivation of the ROR family of orphan nuclear receptors.

Date: 2007
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DOI: 10.1038/nature05767

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