Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Ming T. Cheah, Andreas Wachter, Narasimhan Sudarsan and Ronald R. Breaker ()
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Ming T. Cheah: Cellular and Developmental Biology;
Andreas Wachter: Cellular and Developmental Biology;
Narasimhan Sudarsan: Cellular and Developmental Biology;
Ronald R. Breaker: Cellular and Developmental Biology;

Nature, 2007, vol. 447, issue 7143, 497-500

Abstract: Riboswitches are elements present in some mRNAs that form alternative folded structures depending on the presence or absence of a small molecule ligand. These alternative structures determine whether protein is made from the mRNA. Here, a new way by which riboswitches affect protein expression, by affecting alternative splicing, is described.

Date: 2007
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DOI: 10.1038/nature05769

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