Experimental and theoretical study of mitotic spindle orientation

Manuel Théry, Andrea Jiménez-Dalmaroni, Victor Racine, Michel Bornens () and Frank Jülicher ()
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Manuel Théry: Institut Curie, CNRS UMR144, Compartimentation et Dynamique Cellulaire, 26 rue d’Ulm, 75248 Paris, France
Andrea Jiménez-Dalmaroni: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany
Victor Racine: Institut Curie, CNRS UMR144, Compartimentation et Dynamique Cellulaire, 26 rue d’Ulm, 75248 Paris, France
Michel Bornens: Institut Curie, CNRS UMR144, Compartimentation et Dynamique Cellulaire, 26 rue d’Ulm, 75248 Paris, France
Frank Jülicher: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany

Nature, 2007, vol. 447, issue 7143, 493-496

Abstract: Axis of cell division The orientation of the cell division axis is critical for normal growth and development as it determines the fate of future daughter cells. The extracellular matrix that the cells adhere to plays a role in determining the orientation of the division axis. A combination of experiment in HeLa cells and quantitative theory has shown that spindle orientation is controlled by cortical force generators based on cues from the geometry of the cellular microenvironment. A simple model based on pulling forces exerted by force generators on spindle microtubules can quantitatively describe spindle orientations in many different geometries.

Date: 2007
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DOI: 10.1038/nature05786

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