Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

G. C. Fox, M. Shafiq, D. C. Briggs, P. P. Knowles, M. Collister, M. J. Didmon, V. Makrantoni, R. J. Dickinson, S. Hanrahan, N. Totty, M. J. R. Stark, S. M. Keyse and N. Q. McDonald ()
Additional contact information
G. C. Fox: Structural Biology Laboratory and,
M. Shafiq: Structural Biology Laboratory and,
D. C. Briggs: Structural Biology Laboratory and,
P. P. Knowles: Structural Biology Laboratory and,
M. Collister: Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK
M. J. Didmon: Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK
V. Makrantoni: College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, UK
R. J. Dickinson: Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK
S. Hanrahan: Protein Analysis Laboratory, The London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
N. Totty: Protein Analysis Laboratory, The London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
M. J. R. Stark: College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, UK
S. M. Keyse: Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK
N. Q. McDonald: Structural Biology Laboratory and,

Nature, 2007, vol. 447, issue 7143, 487-492

Abstract: The stress-induced yeast MAPK phosphatase Sdp1 acquires enhanced activity under oxidative conditions by forming an intramolecular disulphide bond that is used to recognize a tyrosine-phosphorylated substrate.

Date: 2007
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DOI: 10.1038/nature05804

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