The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Mamta Tahiliani, Pinchao Mei, Rui Fang, Thiago Leonor, Michael Rutenberg, Fumiko Shimizu, Jing Li, Anjana Rao and Yujiang Shi ()
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Mamta Tahiliani: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Pinchao Mei: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Rui Fang: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Thiago Leonor: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Michael Rutenberg: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Fumiko Shimizu: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Jing Li: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
Anjana Rao: Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Yujiang Shi: Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue

Nature, 2007, vol. 447, issue 7144, 601-605

Abstract: Mental retardation link A protein previously implicated in X-linked mental retardation has now been found to influence gene expression by modifying histones. The JmjC-domain-containing protein SMCX (or JARID1C) is a histone demethylase that demethylates H3 trimethylated at lysine 4, both in vitro and in cells, and can repress transcription of certain neuronal genes. The finding suggests that mutations in SMCX might contribute to disease by impairing regulation of neuronal genes via this effect on chromatin.

Date: 2007
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DOI: 10.1038/nature05823

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