8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Giovanni Maga (), Giuseppe Villani, Emmanuele Crespan, Ursula Wimmer, Elena Ferrari, Barbara Bertocci and Ulrich Hübscher
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Giovanni Maga: Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy
Giuseppe Villani: Institute de Pharmacologie et de Biologie Structurale, IPBS-CNRS, Centre National de la Recherche Scientifique, Route de Narbonne 205, 31077 Toulouse, France
Emmanuele Crespan: Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy
Ursula Wimmer: Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Elena Ferrari: Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Barbara Bertocci: Institute National Français de Recherche Médicale, Université Paris Descartes, Faculté de Médecine René Descartes, Site Necker-Enfants Malades, 156 rue de Vaugirard 75730 Paris, Cedex 15, France
Ulrich Hübscher: Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Nature, 2007, vol. 447, issue 7144, 606-608

Abstract: The replication accessory proteins PCNA and RPA are unexpectedly able to stimulate the activity of some of the polymerases that catalyse DNA synthesis. It is speculated that the ability of some polymerases to have their activity enhanced in this way sets up a hierarchy of polymerase utilization at DNA lesions.

Date: 2007
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DOI: 10.1038/nature05843

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