Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

Brian J. Yeh, Robert J. Rutigliano, Anrica Deb, Dafna Bar-Sagi () and Wendell A. Lim ()
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Brian J. Yeh: Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, San Francisco, California 94158-2517, USA
Robert J. Rutigliano: School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Anrica Deb: UCSF/UCB NIH Nanomedicine Development Center, University of California, San Francisco, San Francisco, California 94158-2517, USA
Dafna Bar-Sagi: School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Wendell A. Lim: UCSF/UCB NIH Nanomedicine Development Center, University of California, San Francisco, San Francisco, California 94158-2517, USA

Nature, 2007, vol. 447, issue 7144, 596-600

Abstract: In a synthetic biology approach, GEF domains from Rho GTPases are combined with novel regulatory domains to link cytoskeletal responses to normally unrelated upstream signalling pathways.

Date: 2007
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DOI: 10.1038/nature05851

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