Dscam2 mediates axonal tiling in the Drosophila visual system

S. Sean Millard, John J. Flanagan, Kartik S. Pappu, Wei Wu and S. Lawrence Zipursky ()
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S. Sean Millard: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
John J. Flanagan: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Kartik S. Pappu: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Wei Wu: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
S. Lawrence Zipursky: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA

Nature, 2007, vol. 447, issue 7145, 720-724

Abstract: The role of Dscam2 (an immunoglobin superfamily protein) in regulating formation of precise patterns of synaptic connections in the Drosophila visual system is described, and shows for the first time that Dscam2 limits connections through a tiling mechanism that involves homotypic repulsion.

Date: 2007
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DOI: 10.1038/nature05855

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