Resolvin E1 and protectin D1 activate inflammation-resolution programmes

Jan M. Schwab, Nan Chiang, Makoto Arita and Charles N. Serhan ()
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Jan M. Schwab: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nan Chiang: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Makoto Arita: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Charles N. Serhan: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2007, vol. 447, issue 7146, 869-874

Abstract: This paper examines the role of lipid metabolites of arachidonic acid, docosahexaenoic acid and eicosapentaenoic acid in the resolution of acute inflammation. The omega-3 fatty acids are shown to affect phagocytosis, phagocyte removal, and leukocyte infiltration.

Date: 2007
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DOI: 10.1038/nature05877

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