Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Rolf Thermann and Matthias W. Hentze ()
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Rolf Thermann: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Matthias W. Hentze: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany

Nature, 2007, vol. 447, issue 7146, 875-878

Abstract: Paths to gene silence Two studies this week report on gene silencing by microRNAs (miRNAs), the small RNAs that regulate messenger RNA stability and translation. Chendrimada et al. show that the three-molecule complex RISC, which is known to generate miRNAs, interacts with the MOV10 complex that includes the ribosome anti-association factor eIF6. This points to a role for eIF6 as an evolutionarily conserved mediator of miRNA-directed gene silencing. Rolf Thermann and Matthias Hentze find that the Drosophila miRNA miR2 blocks protein formation by producing large miRNA complexes that strongly resemble ribosomes. mRNAs locked into the resulting pseudo-polysome are effectively put out of action.

Date: 2007
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DOI: 10.1038/nature05878

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