Mechanism of coupled folding and binding of an intrinsically disordered protein

Kenji Sugase, H. Jane Dyson and Peter E. Wright ()
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Kenji Sugase: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
H. Jane Dyson: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Peter E. Wright: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2007, vol. 447, issue 7147, 1021-1025

Abstract: Many proteins that are important to cellular signalling are intrinsically disordered, as they only fold after binding with signalling partners. In this paper the molecular interactions governing such proteins' coupled folding and binding process, and how they differ radically from interactions between pre-folded proteins are described.

Date: 2007
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DOI: 10.1038/nature05858

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