Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

Trista E. North, Wolfram Goessling, Carl R. Walkley, Claudia Lengerke, Kamden R. Kopani, Allegra M. Lord, Gerhard J. Weber, Teresa V. Bowman, Il-Ho Jang, Tilo Grosser, Garret A. FitzGerald, George Q. Daley, Stuart H. Orkin and Leonard I. Zon ()
Additional contact information
Trista E. North: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Wolfram Goessling: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Carl R. Walkley: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Claudia Lengerke: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Kamden R. Kopani: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Allegra M. Lord: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Gerhard J. Weber: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Teresa V. Bowman: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Il-Ho Jang: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Tilo Grosser: Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Garret A. FitzGerald: Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
George Q. Daley: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Stuart H. Orkin: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Leonard I. Zon: Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2007, vol. 447, issue 7147, 1007-1011

Abstract: A tonic to the blood A previously unidentified modulator of vertebrate haematopoietic stem cell (HSC) number has been discovered using a chemical genetic screen in zebrafish. Prostaglandin E2 (PGE2) increases HSCs in the embryo and enhances marrow recovery following irradiation of adult fish. These effects of PGE2 on stem and progenitor cell number are conserved across vertebrate species. This suggests that modulation of this pathway could be used to treat patients undergoing bone marrow transplant and for some forms of anaemia.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature05883 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:447:y:2007:i:7147:d:10.1038_nature05883

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05883

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().