Chromatin dynamics and the preservation of genetic information

Jessica A. Downs, Michel C. Nussenzweig and André Nussenzweig
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Jessica A. Downs: MRC Genome Damage and Stability Centre, University of Sussex
Michel C. Nussenzweig: Howard Hughes Medical Institute, The Rockefeller University
André Nussenzweig: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health

Nature, 2007, vol. 447, issue 7147, 951-958

Abstract: Abstract The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin — the fibres into which DNA is packaged with a proteinaceous structural polymer — has an important role in initiating, propagating and terminating this cellular response to DNA damage.

Date: 2007
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DOI: 10.1038/nature05980

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