Ambra1 regulates autophagy and development of the nervous system

Gian Maria Fimia, Anastassia Stoykova, Alessandra Romagnoli, Luigi Giunta, Sabrina Di Bartolomeo, Roberta Nardacci, Marco Corazzari, Claudia Fuoco, Ahmet Ucar, Peter Schwartz, Peter Gruss, Mauro Piacentini, Kamal Chowdhury () and Francesco Cecconi ()
Additional contact information
Gian Maria Fimia: National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy
Anastassia Stoykova: Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany
Alessandra Romagnoli: National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy
Luigi Giunta: Dulbecco Telethon Institute at the Department of Biology,
Sabrina Di Bartolomeo: Dulbecco Telethon Institute at the Department of Biology,
Roberta Nardacci: National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy
Marco Corazzari: National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy
Claudia Fuoco: Dulbecco Telethon Institute at the Department of Biology,
Ahmet Ucar: Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany
Peter Schwartz: University of Göttingen, 37085 Göttingen, Germany
Peter Gruss: Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany
Mauro Piacentini: National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy
Kamal Chowdhury: Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany
Francesco Cecconi: Dulbecco Telethon Institute at the Department of Biology,

Nature, 2007, vol. 447, issue 7148, 1121-1125

Abstract: The identification of the large protein Ambra-1, which regulates autophagy and plays a crucial role in embryogenesis is described. The absence of Ambra-1 function during development results in severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.

Date: 2007
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DOI: 10.1038/nature05925

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