A microRNA component of the p53 tumour suppressor network

Lin He, Xingyue He, Lee P. Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon, Aimee L. Jackson, Peter S. Linsley, Caifu Chen, Scott W. Lowe, Michele A. Cleary () and Gregory J. Hannon ()
Additional contact information
Lin He: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Xingyue He: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Lee P. Lim: Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA
Elisa de Stanchina: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Zhenyu Xuan: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Yu Liang: Advanced Research & Technology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA
Wen Xue: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Lars Zender: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Jill Magnus: Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA
Dana Ridzon: Advanced Research & Technology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA
Aimee L. Jackson: Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA
Peter S. Linsley: Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA
Caifu Chen: Advanced Research & Technology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA
Scott W. Lowe: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Michele A. Cleary: Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA
Gregory J. Hannon: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA

Nature, 2007, vol. 447, issue 7148, 1130-1134

Abstract: MicroRNAs in cancer The tumour suppressor p53 is the most commonly mutated gene in human cancers, and probably nearly all tumours have a lesion somewhere in this pathway. The p53 network is activated in response to numerous insults to restrain inappropriate cell proliferation either via growth arrest or cell death. MicroRNAs (miRNAs) are increasingly recognized for playing important parts in cancer, but little is know about how miRNA expression is regulated. Now a miRNA component of the p53 tumour suppressor network has been identified: p53 directly activates the transcription of the miR-34 family of miRNAs, which themselves suppress cell proliferation. Though dozens of p53 targets are known in mammals, miR-34 is unusual in that it is also present in Drosophila and the nematode worm C. elegans. This suggests that the link between p53 and miR-34 may have arisen early in the evolution of the p53 network.

Date: 2007
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DOI: 10.1038/nature05939

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