Intronic microRNA precursors that bypass Drosha processing

J. Graham Ruby, Calvin H. Jan and David P. Bartel ()
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J. Graham Ruby: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Calvin H. Jan: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
David P. Bartel: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA

Nature, 2007, vol. 448, issue 7149, 83-86

Abstract: MicroRNAs (miRNAs) are produced through a set of cleavages within a longer RNA, one of the nucleases involved in this process is Drosha. A subset of miRNAs (mirtrons) are matured through an alternative pathway that is Drosha-independent. These mirtrons may be the early ancestors of the majority of miRNAs that were expressed once Drosha function emerged.

Date: 2007
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DOI: 10.1038/nature05983

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